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CDCB Organized by

Yunyu ShiXuebiao Yao, USTC, China

Xing Liu, USTC, China

Early Career Meeting on Yellow Mountain Conference on Single Cell Dynamics Organized by

Jiajia Zhou, Anhui Key Laboratory for Cellular Dynamics & Chemical Biology, China

Wenwen Wang, Anhui Key Laboratory for Cellular Dynamics & Chemical Biology, China

SHI Yunyu


Professor, Member of Chines Academy of Science

School of Life Sciences

University of Science & Technology of China

Tel: 86-551-3607464

Fax: 86-551-3601443

e-mail: yyshi@ustc.edu.cn

Homepage: http://bionmr.ustc.edu.cn/


Personal Profile

1960-1965, Department of biophysics, University of Science and Technology of China, Beijing, Biophysics. 

1965-1970 Assistant researcher, Chinese Traditional Medicine InstituteBeijing

1970- Assistant professor, Lecturer, Associate professor, Professor, Department of Biologysince 1998, It was changed to School of Life Science, University of Science and Technology of China,

Visiting scholar, at Department of Chemistry of Roma University and CNRS Lab. of Structural Chemistry, Italy; Department of Chemistry, University of Groningen, Netherlands; CNRS Lab. of Structural Biology, Gif-Yvette, France; CNRS Lab. of Theoretical Chemistry, University of NANCY, France, respectively.


Research Interests

We are interested in gene regulation, especially epigenetic regulation, such as histone modifications, chromatin remodeling, and ncRNA regulation. We are also interested in cellular adhesive and migration. We focus on studying structural basis and molecular mechanism underline the cellular differentiation and human disease especially invasion and migration of tumor cell.

We are interested in the structure, dynamics, and function of protein, RNA, and interactions between protein-protein, protein-nucleic acid, protein-ligand. We try to understand the principle underlie the molecular recognition, and to elucidate biological implications of these interactions.

Structural biology methods are our major tools (NMR and crystallography). We also use different methods including methods of molecular biology, biochemistry, cell biology and biophysics to solve our problems.


YAO Xuebiao



Cheung Kong Scholar

Anhui Key Laboratory of Cell Dynamics & Chemical Biology

School of Life Science

University of Science & Technology of China

Tel: 0551-3607141

Fax: 0551-3607141

E-mail: yaoxb@ustc.edu.cn

Homepage: http://lcdcb.ustc.edu.cn/


Personal Profile:

Dr. Xuebiao Yao received his Ph.D. from University of California at Berkeley under Professor John Forte’s supervision in 1995, and pursued a postdoctoral fellowship at the Ludwig Institute for Cancer Research with Professor Don Cleveland before joining the faculty of the University of Wisconsin-Madison as an Assistant Professor in 1998. He was selected as a Chueng Kong Scholar of the Ministry of Education and received an Outstanding Young Scientist Award from Natural Science Foundation of China in 1999. Dr. Yao built the Laboratory of Cellular Dynamics in the University of Science & Technology in 2000 and became the Principal Investigator for the State-sponsored Key Basic Science project titled “Regulatory protein interacting networks underlying cell division” in 2002. Dr. Yao’s research interest is centered on the molecular mechanisms underlying cellular plasticity and dynamics. Using kinetochore as a model system, his research team has identified several important kinetochore interacting networks and pathways essential for accurate chromosome segregation. Among many affiliated responsibilities, Dr. Yao serves as an Associate Editor of Journal of Molecular & Cell Biology, and board members of Journal of Biological Chemistry and Cell Research.


Research Interests:

Cellular polarity in health and diseases:

Our research objectives are directed to understand cellular mechanisms involved in establishment and maintenance of cell polarity. In addition, we are interested in delineating how extracellular cues such as cytokine and growth factors change the epithelial cell plasticity and induce directional movements such as organ-specific tumor metastasis.

Mitotic chromosome segregation and genomic stability:

We are delineating how protein-protein interactions at the kinetochore are orchestrated during cell division and what happens when specific protein-protein interaction is perturbed in real-time live cells using an array of optical reporters.




©Laboratory of Cellular Dynamics, USTC, All Rights Reserved.
Address: Laboratory of Cellular Dynamics, University of Science & Technology of China, Hefei, Anhui 230027, China
Tel: +86(551)3607141, 63607821 Fax: +86(551)63607141 Email: USTCLCD@ustc.edu.cn or xgao@mail.ustc.edu.cn