Professor, University of California San Diego, USA
2018 Breakthrough Prize in Life Sciences
For elucidating the molecular pathogenesis of a type of inherited ALS, including the role of glia in neurodegeneration, and for establishing antisense oligonucleotide therapy in animal models of ALS and Huntington’s disease.
Contact Information
Email: dcleveland@ucsd.edu
Tel: Don Cleveland Lab
Researcherid:
Education and Research Experience
Ph.D., Distinguished Professor and Department Chair of Cellular and Molecular Medicine, University of California San Diego. Dr. Don Cleveland is an elected member of National Academy of Sciences 2006, and also an elected member of National Academy of Medicine 2012.
Research Interests
Dr. Don Cleveland’s lab is interested in genome rearrangement in cancer and the mechanism and therapy for human neurodegenerative disease.
Representative Publications
(*: corresponding author)
1.Beccari et al., Stathmin-2 enhances motor axon regeneration after injury independent of its binding to tubulin. Proc Natl Acad Sci U S A. 2025 May 27; 122(21):e2502294122.
2. Krupina et al., Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements. Nat Rev Genet. 2024, 25(3):196-210.
3. Trivedi et al., Mitotic tethering enables inheritance of shattered micronuclear chromosomes. Nature. 2023, 618(7967):1049-1056.
4. Li et al., Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats. Nature. 2023, 616(7957):504-509.
5. Baughn et al., Mechanism of STMN2 cryptic splice-polyadenylation and its correction for TDP-43 proteinopathies. Science. 2023, 379(6637):1140-1149.