Xuebiao YAO Professor Anhui Key Laboratory of Cell Dynamics & Chemical Biology School of Life Science University of Science & Technology of China Tel: 0551-3607141 Fax: 0551-3607141 Email: yaoxb@ustc.edu.cn Homepage: http://mklcd.ustc.edu.cn/ Research Interests: Cellular polarity in health and diseases: Our research objectives are directed to understand cellular mechanisms involved in establishment and maintenance of cell polarity. In addition, we are interested in delineating how extracellular cues such as cytokine and growth factors change the epithelial cell plasticity and induce directional movements such as organ-specific tumor metastasis. Mitotic chromosome segregation and genomic stability: We are delineating how protein-protein interactions at the kinetochore are orchestrated during cell division and what happens when specific protein-protein interaction is perturbed in real-time live cells using an array of optical reporters. Organoids: Organoids are miniature, three-dimensional cell culture models that improved from stem cell and 3D cell culture approaches which can be made from tissues and studied the cellular dynamics and cell-cell communication under a microscope. This newly stablished model allows researchers to model cell biology and disease mechanisms. As visualization of specific molecules and their interactions in space and time is essential to delineate how cellular plasticity is orchestrated, we must overcome the limitation of optical imaging and the robustness and reproducibility of organoids. This quest requires synergism among photonics, chemistry, clinical medicine, and biology. | 
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